Corrigendum: Small molecule–based reversible reprogramming of cellular lifespan
نویسندگان
چکیده
منابع مشابه
Retraction: small molecule-based reversible reprogramming of cellular lifespan.
In this paper, we described the application of magnetism-based interaction capture (MAGIC) to find a small-molecule protein target. MAGIC identified the protein ATM as the target of CGK733, a small molecule reportedly isolated by high-throughput screening. A preliminary investigation of the contents of the paper by Korean Advanced Institute of Science and Technology (KAIST) has revealed several...
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Most somatic cells encounter an inevitable destiny, senescence. Little progress has been made in identifying small molecules that extend the finite lifespan of normal human cells. Here we show that the intrinsic 'senescence clock' can be reset in a reversible manner by selective modulation of the ataxia telangiectasia-mutated (ATM) protein and ATM- and Rad3-related (ATR) protein with a small mo...
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a:4:{s:10:"Background";s:1707:"Early embryonic development in mammals begins in transcriptional silence with an oocyte-mediated transcriptional reprogramming of parental gametes occurs during a so called across-the-board process of “erase-and-rebuild”. In this process, the parental transcription programs are erased long before (maternal) or soon thereafter (paternal) fertilization to generate a...
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The day we understand the time evolution of subcellular events at a level of detail comparable to physical systems governed by Newton's laws of motion seems far away. Even so, quantitative approaches to cellular dynamics add to our understanding of cell biology. With data-guided frameworks we can develop better predictions about, and methods for, control over specific biological processes and s...
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Studies of network map are very important, because they help us to understand the basic features and requirements of various systems. So far many connection topologies of network assumed to be either completely regular or completely random have been studied in the past. Cellular Neural Network (CNN) model invented by Chua and Yang in 1988 [1] is a typical of those completely local connectivitie...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2007
ISSN: 1552-4450
DOI: 10.1038/nchembio0207-126a